Collingwood has named captain Scott Pendlebury among fives changes for the clash against Melbourne at the Gabba on Saturday.
Pendlebury has missed the past four games with a quadriceps strain, senior coach Nathan Buckley declaring the Pies skipper was ready to go on Friday.
"Tomorrow can’t come soon enough for Pendles, because he’s right to go,” Buckley said in his press conference.
"He is right to go and looking forward to playing.
"He has done everything in his power and he is up and physically ready to go."
Jamie Elliott and Will Hoskin-Elliott are welcome additions to face Melbourne after missing round 11 with minor injuries.
Ben Reid and Darcy Moore come back into the line-up after being managed through the compressed fixture.
Jordan Roughead (concussion) and Brayden Sier (quad) will miss round 12 after sustaining injuries in the win over the Crows.
Tim Broomhead, Jaidyn Stephenson and Chris Mayne have been omitted from the side.
FIXTURE CONFIRMED: Pies to face Blues, Lions and Suns
The first bounce at the Gabba is set for 5.10pm (AEST). Tune in live on Fox Footy, Kayo and on AFL Live Pass.
Melbourne v Collingwood
AFL Round Twelve
Saturday 15 August
B: Jack Crisp, Darcy Moore, Jack Madgen
HB: Brayden Maynard, Lynden Dunn, John Noble
C: Tom Phillips, Steele Sidebottom, Josh Daicos
HF: Brody Mihocek, Ben Reid, Will Hoskin-Elliott
F: Callum Brown, Darcy Cameron, Jamie Elliott
Foll: Brodie Grundy, Taylor Adams, Scott Pendlebury
Int: Travis Varcoe, Rupert Wills, Josh Thomas, Trey Ruscoe
In: Jamie Elliott, Scott Pendlebury, Ben Reid, Darcy Moore, Will Hoskin-Elliott
Out: Brayden Sier (quad), Jaidyn Stephenson (omitted), Jordan Roughead (concussion), Tim Broomhead (omitted), Chris Mayne (omitted)
Emerg: Tim Broomhead, Chris Mayne, Matt Scharenberg, Mark Keane